On December 11, 2024, Polyseq Biotechnology released its new product, PolyseqHive, in Beijing. Gene sequencing users and researchers from all walks of life witnessed Polyseq's significant technological leap in the field of nanopore sequencing.
Continuous product releases lead to a significant improvement in system performance
At the press conference, Gong Mingtao, Product Manager of Polyseq Biotechnology, introduced the new generation of nanopore sequencer PolyseqHive to the attendees. PolyseqHive brings unprecedented flexibility and high-throughput experience to users with its outstanding 6-chip independent control capability. Its sequencing time can cover 1 minute to 72 hours, and the sequencing flux range is from 1 Mb to 360 Gb. Whether it is a simple and fast on-site sequencing scenario or a complex sequencing task for large-scale genomes, PolyseqHive can easily handle it, making it an ideal choice for diversified sequencing scenarios in scientific research and clinical fields.
With a strong R&D team and profound technical accumulation, Polyseq Biotechnology's nanopore sequencing product technology has rapidly iterated, and various sequencing indicators have significantly improved. For example, the sequencing speed of the Polyseq nanopore system has been increased from 350 nt/s to 420 nt/s, the continuous sequencing time has been increased from 48 hours to 72 hours, and the single-chip sequencing throughput has been increased from 10 Gb to stable delivery of 20 Gb. However, the technological pursuit of ordinary people is not extreme. In the laboratory, the single-chip data throughput of the Polyseq nanopore system has reached 50 Gb, and the sequencing time has exceeded 144 hours. The founder team's years of research and development accumulation have strongly supported the rapid iterative development of sequencing technology and the continuous improvement of product performance, which is also the biggest advantage of Polyseq Biotechnology.
Hardcore on-site sequencing, witnessing the lead ahead
At the press conference, Polyseq Biotechnology conducted a full-scale on-site test demonstration using the PolyseqHive nanopore sequencer, which was also live streamed online simultaneously. The attending guests witnessed the live sequencing of 6 independent control units of PolyseqHive chips together. The on-site/live broadcast displayed real-time measured data and quality control results, allowing the audience to experience the real sequencing scene face-to-face!
Polyseq Biotechnology has also launched multiple sequencing kits to meet the diverse sequencing needs of customers in different scenarios. Taking the Barcode tagging library kit and chip cleaning kit launched on site as examples, not only can they significantly improve data throughput, but they can also effectively control sequencing costs and solve cost concerns for users when applying sequencing platforms. In the future, with the continuous launch of more new products, the commercial application of nanopore sequencing will be greatly popularized.
Application customer likes, future new products are expected
At the press conference, Polyseq Biotechnology was honored to invite Dr. Yu Yang from Guangzhou Women and Children's Medical Center, the application customer of the company's first commercial nanopore sequencer PolysseqOne, to share his experience and future application directions of the nanopore sequencer on site. Researcher Yu Yang demonstrated the use of PolysseqOne in his laboratory for sequencing data of higher animals and plants, with over 20 Gb of data in 48 hours, an average read length of 15 Kb, and a maximum read length>300 Kb. The single sequence accuracy exceeded 97%, and the client was truly impressed. As of now, the installed capacity of PolyseqOne has exceeded 100 units, and positive feedback from customers indicates that its sequencing performance has passed the first round of market testing.
The efficient sequencing of the human genome and the genomes of large animals and plants is of great significance for the prevention and treatment of various genetic diseases, a deeper understanding of species evolutionary relationships, and biodiversity conservation. Polyseq Biotechnology will adhere to the original intention of "making life better", accelerate the research and development process of nanopore sequencing technology, and empower human health and exploration of the mysteries of life. In 2025, Polyseq Biotechnology will successively release multiple products such as high-throughput sequencing chips, high-throughput sequencers, high-precision sequencing systems, and automated library building equipment. We sincerely invite global partners to pay attention to them together.
Introduction to General Translation
Beijing Polyseq Biotechnology Co., Ltd. was established in November 2021, focusing on the research and commercialization of biological nanopore gene sequencing systems. Based on the principle of nanopore gene sequencing, the company constructs a sequencing chemistry system with independent intellectual property rights, using a newly independently analyzed biological nanopore atomic horizontal structure as the foundation, combined with nucleic acid chemistry, protein engineering, etc; Build a high-level sequencing platform using integrated circuit chips, software engineering, and deep learning algorithms; Developing high-precision, high-throughput, long read, low-cost nanopore sequencers and supporting reagents and consumables, enabling gene sequencing technology to enter medical institutions at all levels, benefiting the public, safeguarding the lives and health of the people, and meeting the needs of precision medicine in the era of big data.
