EN

CN
Home > Products > Nanopore Sequencing Technology

Polyseq Nanopore Sequencing Technology

Principle of Nanopore Sequencing
Nanopore proteins are embedded in an insulating polymer membrane, with electrolyte solutions on both sides. Due to the negative charge of nucleic acids in solution, under an applied electric field, single-stranded DNA or RNA is driven from the negative electrode side (cis) toward the positive electrode side (trans) through the nanopore. Simultaneously, electrolyte ions flow through the nanopore, generating an ionic current across the membrane. As different nucleotides have distinct volumes and electrical properties, the ionic current fluctuates in a characteristic manner. By recording these current changes and interpreting the resulting signal patterns, sequencing is achieved.

Contact us
Sequencing Chip

Provides structural support for nanopores, creates the electrochemical environment for electrophoresis, controls multiple channels, and measures and records the current changes as DNA strands pass through the nanopores.

Sequencing Software

Controls the operation of the sequencer, decodes electrical signals, and converts them into nucleotide sequences.

Polyseq Chemistry System

The biochemical system of nanopore sequencing directly influences key performance metrics such as accuracy, speed, throughput, and stability. It encompasses core elements: motor proteins (helicases) with speed control, nanopore proteins, membranes, sequencing adapters, and signal acquisition and decoding components. With structural biology of transmembrane proteins as the foundational research starting point, Polyseq Biotechnology’s core team has expanded over years into novel nanopore protein discovery, sequencing biochemistry development, performance optimization, and industrial-scale technology translation, forming a complete research-to-product pipeline: basic research → technological breakthrough → product commercialization.
Sequencing Biochemistry System

Motor Protein (Helicase)

Precisely “transports” nucleic acid molecules.

Nanopore Protein

Performs the critical task of “recognizing” nucleotides.

Artificial Membrane

Provides a stable environment for embedding membrane proteins while forming a “closed circuit” for current detection.

Algorithm Software

Decodes signals and enables real-time monitoring and control of the sequencing process.

Signal Acquisition & Output

MEMS and ASIC chips enable high-precision current signal acquisition and output.

Sequencing Adapters

Bind to motor proteins and link nucleic acid sequences.

Core Advantages of Polyseq

  • Top Talent + Fully Domestic Technology Chain

    Founder Dr. Yihua Huang is a globally recognized expert in nanopore sequencing, with research that led to the first commercial biological nanopore sequencer. Core technologies are fully independent and domestically developed, forming a comprehensive intellectual property system. Raw read accuracy reaches 99% (Q20), with over 270+ IP achievements, creating a solid technological barrier.

    0
    %

    Raw Read Accuracy

    0
    +

    IP Achievements

  • Focused Portfolio
    High-Performance Product Matrix

    Dedicated to the R&D and commercialization of biological nanopore gene sequencing platforms, offering a full spectrum of low-, medium-, and high-throughput sequencers and compatible consumables. Combines high accuracy, long read lengths, and low cost to precisely meet diverse needs.

  • Full-Scenario Compatibility
    Mission of Accessible Healthcare

    Supports the implementation of multiple sequencing technologies, serving fields such as pathogen detection, genetic disease screening, and precision medicine. Upholds the mission of “making sequencing accessible to all” and aligns with the demand for precision medicine in the big-data era.

  • Rapid Industrialization + Strong Market Penetration

    Achieved the leap from research to industrialization in just over 4 years, delivering 150+ products across multiple scenarios. Rich strategic partnerships have enabled entry into research, medical, disease control, and other channels, with rapid sales growth positioning the company as a core player in the domestic sequencer market.

    0
    year+

    Completed the Leap from Scientific Research to Industrialization

    0
    unit+

    Delivered Multi-Scenario Products

  • National Endorsement
    Authoritative Industry Recognition

    Leads and participates in multiple national key R&D programs, receiving special funding from the Chinese Academy of Sciences and other institutions.
    Founder serves as Chief Scientist of the National Key R&D Program “Third-Generation Sequencer”, demonstrating dual validation of scientific strength and industry standing.

Contact Us

Please fill in the information below, and we will get in touch with you as soon as possible!

x
Our use of cookies
We would like to use necessary cookies to improve your browsing experience and the quality of our website. We would also like to set analytics cookies and advertisement cookies that help us make improvements by measuring how you use our website. Detailed information about the use of cookies on this website and how you can control your consent can be found in our Cookie Policy and Privacy Policy.
Accept only strictly necessary cookies Accept all cookies