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The brand-new C2.0 High-Precision Sequencing Chemistry System
Redefining the benchmark for high accuracy in nanopore sequencing
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Core Technology Breakthrough: Dual-Protein Synergy + Intelligent Algorithm for Enhanced Accuracy
The C2.0 system achieves comprehensive optimization from hardware core to algorithmic logic, constructing a "High-Accuracy Sequencing Closed Loop":
New Protein Combination Laying the Hardware Foundation
The system adopts a novel combination of nanopore proteins and motor proteins. The C2.0 nanopore features a more refined pore structure, significantly improving the signal-to-noise ratio of electrical currents. Paired with the new speed-control protein for precise regulation of sequencing speed, this ensures clearer identification of base signals. Compared to the previous generation C1.0 pore protein, the C2.0 sequencing current amplitude has increased from 65 pA to 100 pA, with the signal-to-noise ratio improved by over 50%, providing robust support for high-accuracy decoding.
Breakthrough in Sequencing Current Amplitude
Significant Improvement in Signal-to-Noise Ratio
Basecall Intelligent Decoding Algorithm
Unleashing Hardware Potential
The Basecall algorithm, specifically customized for the new protein combination, efficiently decodes the correspondence between electrical current signals and nucleotide bases. This enables a single-pass sequencing accuracy exceeding 99%, with the median raw read quality (Q-score) leaping from Q15 to Q20. This advancement breaks the application limitations of traditional nanopore sequencing, which was primarily focused on pathogen detection.
Single-pass Sequencing Accuracy
Median Raw Read Quality(Q-score)
Scenario-Based Value: Covering Multiple Fields, Meeting High-Demand Requirements
With its stable and high-accuracy performance, the C2.0 High-Precision Sequencing Chemistry System has become a "reliable partner" for research across multiple fields:
Genetic Disease Research
Genetic disease diagnosis demands stringent sequencing accuracy. The Q20 high-precision standard significantly reduces false positives and false negatives, providing more accurate data support for pathogenic gene localization and genetic risk assessment, thereby driving breakthroughs in clinical-grade research.
Pan-Species Sequencing
Whether for plant and animal genome analysis, microbial diversity studies, or sequencing of microbes from extreme environments, the C2.0 system consistently delivers Q20 raw read accuracy. It is well-suited for the complex genomic structures of diverse species, delivering high-quality data for fundamental life sciences research and industrial applications such as plasmid sequencing and HLA sequencing.
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